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HRID2200498

反应详情

EQUATION

反应方程式

HRID 2200498 的结构方程式

REACTANTS

反应物

2
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：Cc1ccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)cnc2C#N)cc1
HCID86685615

未命名化合物

PRODUCTS

生成物

1
结构：Cc1ccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)cnc2C(N)=O)cc1
HCID86685616

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：OO
催化剂HCID784

Hydrogen peroxide

H2O2

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To a solution of 5-((3R,4R)-3-aminotetrahydro-2H-pyran-4-ylamino)-3-(p-tolylamino)pyrazine-2-carbonitrile in methanol (1 ml) was added K2CO3 (excess) and H2O2 (50%, a few drops). After completion, it was concentrated and purified by preparative HPLC to give 5-((3R,4R)-3-aminotetrahydro-2H-pyran-4-ylamino)-3-(p-tolylamino)pyrazine-2-carboxamide. MS found for C17H22N6O2 as (M+H)+343.3, UV: λ=251.2, 302.9.

WORKUP

后处理

  1. concentrationAfter completion, it was concentrated
  2. custompurified by preparative HPLC