2-(3-Methoxyphenyl)-4-methyloxazole → HCID 59679628, compound

HRID 2200562Notes

Reaction equation

HRID 2200562 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([C:9]2[O:10][CH:11]=[C:12]([CH3:14])[N:13]=2)[CH:6]=[CH:7][CH:8]=1>Br>[CH3:14][C:12]1[N:13]=[C:9]([C:5]2[CH:4]=[C:3]([OH:2])[CH:8]=[CH:7][CH:6]=2)[O:10][CH:11]=1

Participants

3

Reactant 1

HCID 686696072-(3-Methoxyphenyl)-4-methyloxazole

Product 1

HCID 59679628HCID 59679628, compoundYield 95.6%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

A solution of 2-(3-methoxyphenyl)-4-methyloxazole (1.1 g, 5.79 mmol) in aqueous hydrogen bromide (10 mL, 48% w/w) was heated to 100° C. for 16 h. The mixture was concentrated to give 3-(4-methyloxazol-2-yl)phenol (0.97 g, crude), which was used without purification. LCMS MH+ 176.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-ba6771fb9bb042fd8a3a07edbacda34e
Source dataset
uspto-grants-2016_06
Patent number
US09359359B2

Reaction notes

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