反应详情

In DCM (50 mL) was dissolved the above product ethyl 4-((3-fluoro-4-methoxybenzyl)amino)-2-(methylsulfinyl)pyrimidine-5-carboxylate. To the solution were added 3-azabicyclo[3.1.0]hexan hydrochloride salt (0.8 g, 6.67 mmol) and triethylamine (4 mL, 28.8 mmol). The reaction was conducted at ambient temperature for 18 h, followed by addition of water and extraction with DCM. The organic phase was dried over sodium sulfate, and the solvent was removed by rotary evaporation to give ethyl 2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-((3-fluoro-4-methoxybenzyl)amino)pyrimidine-5-carboxylate as a faint yellow oil (3.1 g). The product was used in the subsequent procedure without further purification.

1. dry with materialThe organic phase was dried over sodium sulfate
2. customthe solvent was removed by rotary evaporation