Hydrochloric Acid → 1-Aminocyclopentane-1-carboxamide hydrochloride

HRID 2201151Notes

Reaction equation

HRID 2201151 reaction equation
[C:1]([C:4]1([NH:9]C(=O)OC(C)(C)C)[CH2:8][CH2:7][CH2:6][CH2:5]1)(=[O:3])[NH2:2].[ClH:17]>O1CCOCC1>[ClH:17].[NH2:9][C:4]1([C:1]([NH2:2])=[O:3])[CH2:8][CH2:7][CH2:6][CH2:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 106808671-Tert-butoxycarbonylamino-1-cyclopentanecarboxamide

Product 1

HCID 545931881-Aminocyclopentane-1-carboxamide hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of tert-butyl 1-carbamoylcyclopentylcarbamate (305 mg, 1.33 mmol) in 4N HCl in dioxane (5 mL) and aq. 6N HCl (3 mL) was stirred at room temperature for 3 h. It was then concentrated in vacuo to give 1-aminocyclopentanecarboxamide hydrochloride as a solid (214 mg).

Workup

  1. concentrationIt was then concentrated in vacuo

Sources & evidence

ORD record
ord-4036f8f0fed94f1b833b2e6ce1196f41
Source dataset
uspto-grants-2016_06
Patent number
US09359375B2

Reaction notes

Loading…