3-Amino-1,2-propanediol → HCID 86723442, compound

HRID 2201199Notes

Reaction equation

HRID 2201199 reaction equation
[C:1]([C:9]1[C:10](=[O:20])[N:11]([CH3:19])[C:12](=[O:18])[N:13]([CH3:17])[C:14]=1[CH2:15]Br)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:21][CH2:22][CH:23]([OH:26])[CH2:24][OH:25]>CCO>[OH:26][CH:23]([CH2:24][OH:25])[CH2:22][N:21]1[C:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[C:9]2[C:14]([N:13]([CH3:17])[C:12](=[O:18])[N:11]([CH3:19])[C:10]2=[O:20])=[CH:15]1

Participants

4

Reactant 2

HCID 735613-Amino-1,2-propanediolHCID 9503195-Benzoyl-6-(bromomethyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione2×

Product 1

HCID 86723442HCID 86723442, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5-Benzoyl-6-(bromomethyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione (Intermediate C)(670 mg, 1.987 mmol), 3-aminopropane-1,2-diol (0.231 ml, 2.98 mmol) and TEA (0.554 ml, 3.97 mmol) were combined in EtOH (15 ml) and heated at reflux for 15 mins.

Workup

  1. temperatureheated
  2. temperatureat reflux for 15 mins

Sources & evidence

ORD record
ord-3fdafe6202b149a29d2855bb81f7ff56
Source dataset
uspto-grants-2016_06
Patent number
US09359381B2

Reaction notes

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