反应详情

Lithium hydroxide monohydrate (1.158 g, 27.6 mmol) was added to a suspension of methyl 4-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)butanoate (Example 9 Step 5) (10 g, 26.3 mmol) in THF (99 ml) and water (32.9 ml). The mixture was stirred for 2 hours and evaporated under vacuum to afford the title compound.

1. customevaporated under vacuum