反应详情

温度

50 °C

A mixture of 0.57 g of 2-ethylsulfanyl-N-[2-hydroxy-5-(pentafluoroethyl)phenyl]nicotinamide, 0.54 g of DMEAD, 0.57 g of triphenylphosphine and 6 ml of THF was stirred at 50° C. for 4 hours. A saturated aqueous ammonium chloride solution was poured to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, then dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 0.35 g of 2-(2-ethylsulfanylpyridin-3-yl)-5-(pentafluoroethyl)benzoxazole (hereinafter, referred to as Compound of Present Invention 36).

1. extractionthe mixture was extracted with ethyl acetate
2. washThe organic layer was washed with water
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationconcentrated under reduced pressure