Ethyl Acetate → HCID 87056044, compound

HRID 2201556Notes

Reaction equation

HRID 2201556 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[O:11])[NH:9][CH:8]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=3)[NH:7][C:6]=2[N:19]=1.[F:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[O:28][C:29]3[CH:39]=[C:38]([N:40]([CH3:45])[S:41]([CH3:44])(=[O:43])=[O:42])[C:37](B4OC(C)(C)C(C)(C)O4)=[CH:36][C:30]=3[C:31]=2[C:32]([NH:34][CH3:35])=[O:33])=[CH:23][CH:22]=1.CC(C1C=C(C(C)C)C(C2C=CC=CC=2P(C2CCCCC2)C2CCCCC2)=C(C(C)C)C=1)C.CCOC(C)=O>O1CCOCC1.O.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[F:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[O:28][C:29]3[CH:39]=[C:38]([N:40]([CH3:45])[S:41]([CH3:44])(=[O:42])=[O:43])[C:37]([C:2]4[CH:3]=[CH:4][C:5]5[C:10](=[O:11])[NH:9][CH:8]([C:12]6[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=6)[NH:7][C:6]=5[N:19]=4)=[CH:36][C:30]=3[C:31]=2[C:32]([NH:34][CH3:35])=[O:33])=[CH:23][CH:22]=1

Participants

8

Reactant 4

HCID 8857Ethyl AcetateHCID 111557942-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenylHCID 682394022-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamideHCID 117775045HCID 117775045, compound

Product 1

HCID 87056044HCID 87056044, compoundYield 49%

Reagents, catalysts & solvents 3

HCID 9811564Bis(dibenzylideneacetone)palladiumCatalystHCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

To a solution of 7-chloro-2-(3-fluorophenyl)-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one (66 mg, 0.237 mmol), 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide (100 mg, 0.199 mmol) and K3PO4.3H2O (106 mg, 0.398 mmol) in 1 mL of dioxane and 0.1 mL of water were added X-phos (10 mg) and Pd2(dba)3 (10 mg) under nitrogen. The mixture was heated at 100° C. for 6 h, concentrated in vacuo and the residue was suspended in water. The mixture was extracted with EtOAc and the organic phase was washed with brine, then dried over sodium sulfate. 2-(4-fluorophenyl)-5-(2-(3-fluorophenyl)-4-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-7-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide (60 mg, yield: 49%) was obtained by the prep-TLC (PE:EtOAc=1:2). 1H-NMR (CD3OD, 400 MHz) δ 8.06 (d, J=7.6 Hz, 1H), 7.91˜7.95 (m, 2H), 7.81 (s, 1H), 7.77 (s, 1H), 7.37˜7.40 (m, 1H), 7.32 (d, J=8.0 Hz, 1H), 7.21˜7.27 (m, 3H), 7.02˜7.08 (m, 2H), 5.96 (s, 1H), 3.27 (d, J=6.0 Hz, 3H), 2.90 (s, 3H), 2.80 (s, 3H). MS (M+H)+: 618.

Workup

  1. concentrationconcentrated in vacuo
  2. extractionThe mixture was extracted with EtOAc
  3. washthe organic phase was washed with brine
  4. dry with materialdried over sodium sulfate

Sources & evidence

ORD record
ord-2763e674082b471583194f69ee08a28e
Source dataset
uspto-grants-2016_06
Patent number
US09364482B2

Reaction notes

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