Hydrochloric Acid → HCID 78320096, compound

HRID 2201924Notes

Reaction equation

HRID 2201924 reaction equation
FC(F)(F)C(O)=O.[CH3:8][C:9]([NH:18][C:19](=[O:42])[CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:33]=[CH:32][C:31]([CH2:34][CH2:35][N:36]3[CH2:40][CH2:39][CH2:38][C@H:37]3[CH3:41])=[CH:30][CH:29]=2)=[CH:24][CH:23]=1)([CH3:17])[C:10]([O:12]C(C)(C)C)=[O:11].Cl.O1CCOCC1>>[CH3:17][C:9]([NH:18][C:19](=[O:42])[CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:29]=[CH:30][C:31]([CH2:34][CH2:35][N:36]3[CH2:40][CH2:39][CH2:38][C@H:37]3[CH3:41])=[CH:32][CH:33]=2)=[CH:24][CH:23]=1)([CH3:8])[C:10]([OH:12])=[O:11]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 118558219HCID 118558219, compound

Product 1

HCID 78320096HCID 78320096, compound

Procedure

To (R)-tert-butyl 2-methyl-2-(3-(4′-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)propanamido)propanoate 2,2,2-trifluoroacetate (2.0 mg, 3.37 mol) was added 4M hydrogen chloride in dioxane (0.295 mL, 1.181 mmol). The reaction was stirred at room temperature for 4 h. The mixture was concentrated to give the title compound. LCMS m/z=423.3 [M+H]+.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-da08c2e2189d400dbdf5f623dc428182
Source dataset
uspto-grants-2016_06
Patent number
US09365511B2

Reaction notes

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