Hydrochloric Acid → HCID 78320394, compound

HRID 2201925Notes

Reaction equation

HRID 2201925 reaction equation
FC(F)(F)C(O)=O.[CH3:8][C@@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][C:25]([CH2:28][CH2:29][C:30]([NH:32][C@@H:33]([CH3:41])[C:34]([O:36]C(C)(C)C)=[O:35])=[O:31])=[CH:24][CH:23]=2)=[CH:18][CH:17]=1.Cl.O1CCOCC1>>[CH3:8][C@@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[CH2:14][CH2:15][C:16]1[CH:17]=[CH:18][C:19]([C:22]2[CH:27]=[CH:26][C:25]([CH2:28][CH2:29][C:30]([NH:32][C@@H:33]([CH3:41])[C:34]([OH:36])=[O:35])=[O:31])=[CH:24][CH:23]=2)=[CH:20][CH:21]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 118558210HCID 118558210, compound

Product 1

HCID 78320394HCID 78320394, compound

Procedure

To (S)-tert-butyl 2-(3-(4′-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)propanamido)propanoate 2,2,2-trifluoroacetate (4.4 mg, 7.60 mol) was added 4M hydrogen chloride in dioxane (0.665 mL, 2.66 mmol). The reaction was stirred at room temperature for 4 h. The mixture was concentrated to give the title compound. LCMS m/z=409.4 [M+H]+.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-4e71db130e9446aaa54e534bb4ad43a9
Source dataset
uspto-grants-2016_06
Patent number
US09365511B2

Reaction notes

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