Hydrochloric Acid → HCID 78320717, compound

HRID 2201936Notes

Reaction equation

HRID 2201936 reaction equation
FC(F)(F)C(O)=O.[CH3:8][C@@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][C:25]([CH2:28][CH2:29][C:30]([NH:32][CH2:33][C:34]([O:36]C)=[O:35])=[O:31])=[CH:24][CH:23]=2)=[CH:18][CH:17]=1.[OH-].[Na+].Cl>CO>[CH3:8][C@@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[CH2:14][CH2:15][C:16]1[CH:17]=[CH:18][C:19]([C:22]2[CH:27]=[CH:26][C:25]([CH2:28][CH2:29][C:30]([NH:32][CH2:33][C:34]([OH:36])=[O:35])=[O:31])=[CH:24][CH:23]=2)=[CH:20][CH:21]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 118558228HCID 118558228, compound

Product 1

HCID 78320717HCID 78320717, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of (R)-methyl 2-(3-(4′-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)propanamido)acetate 2,2,2-trifluoroacetate (18 mg, 0.034 mmol) in MeOH (0.5 mL) was added 5M sodium hydroxide (0.048 mL, 0.241 mmol). The reaction was stirred at room temperature overnight. The mixture was added 1M HCl (2 mL) and purified by HPLC to give the title compound. LCMS m/z=395.2 [M+H]+.

Workup

  1. custompurified by HPLC

Sources & evidence

ORD record
ord-5f9060a533a54af28637a5310138ec69
Source dataset
uspto-grants-2016_06
Patent number
US09365511B2

Reaction notes

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