Hydrochloric Acid → HCID 78320718, compound

HRID 2201937Notes

Reaction equation

HRID 2201937 reaction equation
FC(F)(F)C(O)=O.[CH3:8][C@@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][C:25]([C:28]3([C:33]([NH:35][C@@H:36]4[CH2:41][CH2:40][CH2:39][CH2:38][C@H:37]4[C:42]([O:44]CC)=[O:43])=[O:34])[CH2:32][CH2:31][CH2:30][CH2:29]3)=[CH:24][CH:23]=2)=[CH:18][CH:17]=1.[OH-].[Na+].Cl>O1CCOCC1>[CH3:8][C@@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[CH2:14][CH2:15][C:16]1[CH:17]=[CH:18][C:19]([C:22]2[CH:27]=[CH:26][C:25]([C:28]3([C:33]([NH:35][C@@H:36]4[CH2:41][CH2:40][CH2:39][CH2:38][C@H:37]4[C:42]([OH:44])=[O:43])=[O:34])[CH2:32][CH2:31][CH2:30][CH2:29]3)=[CH:24][CH:23]=2)=[CH:20][CH:21]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 130332022HCID 130332022, compound

Product 1

HCID 78320718HCID 78320718, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To (1R,2R)-ethyl 2-(1-(4′-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)cyclohexanecarboxylate 2,2,2-trifluoroacetate (2.7 mg, 4.19 μmol) was added 5M sodium hydroxide (0.017 mL, 0.084 mmol). The reaction was stirred at room temperature overnight. The mixture was neutralized with 4M HCl in dioxane. The mixture was concentrated and triturated with acetonitrile to give the title compound. LCMS m/z=503.5 [M+H]+.

Workup

  1. concentrationThe mixture was concentrated
  2. customtriturated with acetonitrile

Sources & evidence

ORD record
ord-7fe41a6de3f84b7ba38247a09b34b71e
Source dataset
uspto-grants-2016_06
Patent number
US09365511B2

Reaction notes

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