Hydrochloric Acid → HCID 78321034, compound

HRID 2201940Notes

Reaction equation

HRID 2201940 reaction equation
FC(F)(F)C(O)=O.[CH3:8][C@@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][C:25]([C:28]3([C:33]([NH:35][CH2:36][CH2:37][CH2:38][C:39]([O:41]C(C)(C)C)=[O:40])=[O:34])[CH2:32][CH2:31][CH2:30][CH2:29]3)=[CH:24][CH:23]=2)=[CH:18][CH:17]=1.Cl.O1CCOCC1>>[CH3:8][C@@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[CH2:14][CH2:15][C:16]1[CH:17]=[CH:18][C:19]([C:22]2[CH:27]=[CH:26][C:25]([C:28]3([C:33]([NH:35][CH2:36][CH2:37][CH2:38][C:39]([OH:41])=[O:40])=[O:34])[CH2:29][CH2:30][CH2:31][CH2:32]3)=[CH:24][CH:23]=2)=[CH:20][CH:21]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 118558217HCID 118558217, compound

Product 1

HCID 78321034HCID 78321034, compound

Procedure

To (R)-tert-butyl 4-(1-(4′-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)butanoate 2,2,2-trifluoroacetate (2.6 mg, 4.11 μmol) was added 4M hydrogen chloride in dioxane (0.103 mL, 0.411 mmol). The reaction was stirred at room temperature overnight. The mixture was concentrated to give the title compound. LCMS m/z=463.4 [M+H]+.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-68001557dea84ac7b7bbd407e04a6f78
Source dataset
uspto-grants-2016_06
Patent number
US09365511B2

Reaction notes

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