反应详情

温度

0 °C

A solution of (+)-camphorsulfonic acid (1.49 g, 6.42 mmol) in ethyl acetate (37.5 mL) was added to a solution of the crude 7-fluoro-1,1-dimethyl-2,3-dihydro-1H-inden-5-amine in ethyl acetate (15 mL) at room temperature, and the used container was washed with ethyl acetate (7.5 mL). The mixture was stirred at 0° C. for 1 hr, and filtered, and the used filter was washed with ethyl acetate. The filtrate was concentrated under reduced pressure, ethyl acetate (60 mL) was added to the residue, and the mixture was stirred at 0° C. for 2 hr. The precipitate was collected by filtration, washed with ethyl acetate, and dried over at 40° C. to give 7-fluoro-1,1-dimethyl-2,3-dihydro-1H-inden-5-amine (+)-camphorsulfonate (1.38 g, 3.36 mmol, 58%) as pale-yellow crystals.

1. washthe used container was washed with ethyl acetate (7.5 mL)
2. filtrationfiltered
3. filtrationthe used filter
4. washwas washed with ethyl acetate
5. concentrationThe filtrate was concentrated under reduced pressure, ethyl acetate (60 mL)
6. additionwas added to the residue
7. stirringthe mixture was stirred at 0° C. for 2 hr
8. filtrationThe precipitate was collected by filtration
9. washwashed with ethyl acetate
10. customdried over at 40° C.