Acetonitrile → HCID 55023518, compound

HRID 220257Notes

Reaction equation

HRID 220257 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH2:13][CH2:14][NH2:15])[CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH3:12])[CH3:2].[CH3:16][C:17]#N>CO.[Rh]>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH2:13][CH2:14][NH:15][CH2:16][CH3:17])[CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH3:12])[CH3:2]

Participants

5

Reactant 2

HCID 6342AcetonitrileHCID 84069461381-04-2

Product 1

HCID 55023518HCID 55023518, compound

Reagents, catalysts & solvents 2

HCID 23948RhodiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 0.43 g of 2-(3,4-diethoxy-phenyl)-ethylamine in 3 mL MeOH were added 270 mg of 5 wt % Rh/C and 0.22 mL of MeCN. The reaction mixture was stirred under a H2 atmosphere (balloon) for 3 days and then filtrated over a pad of celite and washed with 100 mL MeOH. Concentration in vacuo afforded 0.4 g of [2-(3,4-diethoxy-phenyl)-ethyl]-ethyl-amine as yellow oil.

Workup

  1. filtrationfiltrated over a pad of celite
  2. washwashed with 100 mL MeOH
  3. concentrationConcentration in vacuo

Sources & evidence

ORD record
ord-4201bcdd52af4248abc2684e4a74e334
Source dataset
uspto-grants-2012_06
Patent number
US08202885B2

Reaction notes

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