3-Aminopyridine → HCID 1704483, compound

HRID 2202613Notes

Reaction equation

HRID 2202613 reaction equation
[C:1]([C:3](=[C:7]([S:10][CH3:11])SC)[C:4]([NH2:6])=O)#[N:2].[NH2:12][C:13]1[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=1>CCO>[CH3:11][S:10][C:7]([NH:12][C:13]1[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=1)=[C:3]([C:1]#[N:2])[C:4]#[N:6]

Participants

4

Reactant 2

HCID 100093-AminopyridineHCID 27477462-Cyano-3,3-bis(methylthio)acrylamide

Product 1

HCID 1704483HCID 1704483, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Dissolved 2-cyano-3,3-bis(methylthio)acrylamide I-2 (1.0 g) in EtOH (15 mL), and heated to 75° C. until solids dissolved. 3-Aminopyridine (1.0 eq., 0.608 g) was then added and solution continued stirring for 2 days. Precipitate formed which was found to be product. Reaction was cooled to room temperature and filtered to obtain 2-((methylthio)(pyridin-3-ylamino)methylene)malononitrile as a yellow powder.

Workup

  1. dissolutiondissolved
  2. customPrecipitate formed which
  3. customReaction
  4. filtrationfiltered

Sources & evidence

ORD record
ord-8295c97876384293a17730fa514a6405
Source dataset
uspto-grants-2016_06
Patent number
US09365556B2

Reaction notes

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