Hydrogen chloride-ethyl acetate → HCID 86728091, compound

HRID 2202646Notes

Reaction equation

HRID 2202646 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[CH2:11][CH:12]([OH:28])[CH2:13][N:14]1[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][C:15]1=[O:27].Cl.C(OCC)(=O)C>C(OCC)(=O)C>[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[CH2:11][CH:12]([OH:28])[CH2:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][C:15]1=[O:27]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86728090HCID 86728090, compound

Product 1

HCID 86728091HCID 86728091, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
20 °C

Procedure

To a solution of tert-butyl 4-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxyl propyl)-3-oxopiperazine-1-carboxylate (200 mg, 0.69 mmol) in ethyl acetate (10 mL) was added HCl/ethyl acetate (4 mL). The reaction mixture was stirred at 20° C. overnight, concentrated and used in the next step without further purification. (100 mg, yield 50%) MS (ESI+) e/z: 290.2 [M+1]+.

Workup

  1. concentrationconcentrated
  2. customused in the next step without further purification

Sources & evidence

ORD record
ord-62fe35c3b5f849ada78e52b96e7b3eef
Source dataset
uspto-grants-2016_06
Patent number
US09365555B2

Reaction notes

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