Trifluoroacetic acid → HCID 22376520, compound

HRID 220265Notes

Reaction equation

HRID 220265 reaction equation
C([O:5][C:6](=[O:19])[CH2:7][CH2:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[N:11][CH:10]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:12]1[C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9]([CH2:8][CH2:7][C:6]([OH:19])=[O:5])=[CH:10][N:11]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68412445HCID 68412445, compound

Product 1

HCID 22376520HCID 22376520, compoundYield 251%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 800 mg of 3-isoquinolin-4-yl-propionic acid tert.-butyl ester in 6.2 mL of DCM was added 6.2 mL of TFA. The reaction mixture was stirred for 2 h at rt and evaporated to dryness to yield 1.57 g of 3-isoquinolin-4-yl-propionic acid as the trifluoroacetic acid salt as a brown solid.

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-db9e1456891048f0a1319d995dda2a15
Source dataset
uspto-grants-2012_06
Patent number
US08202885B2

Reaction notes

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