Hydrochloric Acid → HCID 68413839, compound

HRID 220283Notes

Reaction equation

HRID 220283 reaction equation
C(O[C:6](=O)[N:7]([CH2:9][CH2:10][CH2:11][C:12]1[NH:16][C:15]2[CH:17]=[CH:18][CH:19]=[C:20]([NH:21][C:22](=[O:24])[CH3:23])[C:14]=2[N:13]=1)C)(C)(C)C.[ClH:26]>CCOC(C)=O.O1CCOCC1>[ClH:26].[CH3:6][NH:7][CH2:9][CH2:10][CH2:11][C:12]1[NH:16][C:15]2[CH:17]=[CH:18][CH:19]=[C:20]([NH:21][C:22](=[O:24])[CH3:23])[C:14]=2[N:13]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68415475HCID 68415475, compound

Product 1

HCID 68413839HCID 68413839, compound

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 1.84 g of [3-(4-Acetylamino-1H-benzoimidazol-2-yl)-propyl]-methyl-carbamic acid tert-butyl ester in 2.6 mL of EtOAc was treated with 7.75 mL of 4M-HCl in dioxane for 5 h and concentrated in vacuo to yield 1.7 g of N-[2-(3-methylamino-propyl)-1H-benzoimidazol-4-yl]-acetamide hydrochloride salt as yellow solid.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-09004938460a464db11aaa9df23c0658
Source dataset
uspto-grants-2012_06
Patent number
US08202885B2

Reaction notes

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