反应详情

温度

150 °C

A mixture of 4-benzyloxy-2(1H)-pyridone (1 g), 6-bromo-2-ethyl-1-methyl-1H-benzimidazole (1.19 g), N,N′-dimethylethylenediamine (0.530 ml), copper(I) iodide (0.946 g), potassium carbonate (2.06 g) and DMSO (20 ml) was stirred at 150° C. for 2 h. The mixture was added to 28% NH3 solution, and the precipitate was collected. The solid was dissolved in THF, passed through NH silica pad and concentrated in vacuo to give the title compound (986 mg) as a pink solid. A part of the target compound was treated with activated carbon and recrystallized from THF to give 46.1 mg of the title compound as a white solid.

1. customthe precipitate was collected
2. dissolutionThe solid was dissolved in THF
3. concentrationconcentrated in vacuo