Hydrochloric Acid → 4-(Benzyloxy)-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one hydrochloride

HRID 2202904Notes

Reaction equation

HRID 2202904 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]([C:15]2[CH:16]=[CH:17][C:18]3[N:19]([C:21]([CH3:27])=[C:22]([CH:24]4[CH2:26][CH2:25]4)[N:23]=3)[CH:20]=2)[C:11](=[O:28])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:29]>CCOC(C)=O>[ClH:29].[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]([C:15]2[CH:16]=[CH:17][C:18]3[N:19]([C:21]([CH3:27])=[C:22]([CH:24]4[CH2:26][CH2:25]4)[N:23]=3)[CH:20]=2)[C:11](=[O:28])[CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 89690318HCID 89690318, compound

Product 1

HCID 896905354-(Benzyloxy)-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a suspension of 4-(benzyloxy)-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one (50 mg) in EtOAc (3 ml) was added 4 M HCl (EtOAc solution) (0.067 ml), and the mixture was stirred at room temperature for 3 h. The resulting solid was collected, washed with EtOAc, and dried in vacuo to give the title compound (44.0 mg) as a white solid.

Workup

  1. customThe resulting solid was collected
  2. washwashed with EtOAc
  3. customdried in vacuo

Sources & evidence

ORD record
ord-4e00d07da37e4f84b5130cc98bdbfe32
Source dataset
uspto-grants-2016_06
Patent number
US09365540B2

Reaction notes

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