Hydrochloric Acid → 1-(2-Cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-((5-(trifluoromethyl)thiophen-2-yl)methoxy)pyridin-2(1H)-one hydrochloride

HRID 2202979Notes

Reaction equation

HRID 2202979 reaction equation
[ClH:1].[CH:2]1([C:5]2[N:6]=[C:7]3[CH:12]=[CH:11][C:10]([N:13]4[CH:18]=[CH:17][C:16]([O:19][CH2:20][C:21]5[S:22][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:24][CH:25]=5)=[CH:15][C:14]4=[O:30])=[CH:9][N:8]3[C:31]=2[CH3:32])[CH2:4][CH2:3]1>CCOC(C)=O>[ClH:1].[CH:2]1([C:5]2[N:6]=[C:7]3[CH:12]=[CH:11][C:10]([N:13]4[CH:18]=[CH:17][C:16]([O:19][CH2:20][C:21]5[S:22][C:23]([C:26]([F:27])([F:28])[F:29])=[CH:24][CH:25]=5)=[CH:15][C:14]4=[O:30])=[CH:9][N:8]3[C:31]=2[CH3:32])[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 896902751-(2-Cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-((5-(trifluoromethyl)thiophen-2-yl)methoxy)pyridin-2(1H)-one

Product 1

HCID 1213862351-(2-Cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-((5-(trifluoromethyl)thiophen-2-yl)methoxy)pyridin-2(1H)-one hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

4 M HCl in EtOAc (0.714 ml) was added to a solution of 1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-((5-(trifluoromethyl)thiophen-2-yl)methoxy)pyridin-2(1H)-one (1.27 g) in EtOAc (25 ml) at room temperature. The mixture was stirred at room temperature for 2 h. The resulting suspension was filtered and the precipitate was washed with EtOAc. The precipitate was crystallized from EtOH-IPE to give the title compound (0.39 g) as a white solid.

Workup

  1. filtrationThe resulting suspension was filtered
  2. washthe precipitate was washed with EtOAc
  3. customThe precipitate was crystallized from EtOH-IPE

Sources & evidence

ORD record
ord-be8521d03e254778b42a13576311c83a
Source dataset
uspto-grants-2016_06
Patent number
US09365540B2

Reaction notes

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