反应详情

温度

60 °C

To a solution of N-(5-bromo-1-(1-cyclopropyl-1-oxopropan-2-yl)pyrazin-2(1H)-ylidene)-4-methylbenzenesulfonamide (1.24 g) in THF (10 ml) was added trifluoroacetic anhydride (1.23 g) at 0° C., and the mixture was heated at 60° C. for 3 h. The mixture was partitioned between EtOAc and saturated NaHCO3 solution, and the organic layer was washed with 1 M NaOH and brine successively, dried over MgSO4, concentrated in vacuo, and purified by silica gel column chromatography (hexane/EtOAc) to give the title compound (593 mg) as pale yellow crystals.

1. customThe mixture was partitioned between EtOAc and saturated NaHCO3 solution
2. washthe organic layer was washed with 1 M NaOH and brine successively
3. dry with materialdried over MgSO4
4. concentrationconcentrated in vacuo
5. custompurified by silica gel column chromatography (hexane/EtOAc)