反应详情

温度

150 °C

A mixture of 4-((4-chlorobenzyl)oxy)pyridin-2(1H)-one (108 mg), 6-bromo-2-cyclopropyl-3-methylimidazo[1,2-b]pyridazine (150 mg), N,N′-dimethyl-1,2-ethanediamine (81 mg), CuI (87 mg), potassium carbonate (190 mg) and DMSO (3 ml) was heated at 150° C. for 1 h under microwave irradiation. The mixture was poured into 28% NH3 solution, and extracted with EtOAc. The organic layer was separated, washed with water and brine successively, dried over MgSO4, concentrated in vacuo, and purified by column chromatography (hexane/EtOAc), followed by crystalization from EtOAc-hexane to give the title compound (52.3 mg) as pale yellow crystals.

1. extractionextracted with EtOAc
2. customThe organic layer was separated
3. washwashed with water and brine successively
4. dry with materialdried over MgSO4
5. concentrationconcentrated in vacuo
6. custompurified by column chromatography (hexane/EtOAc)
7. customfollowed by crystalization from EtOAc-hexane