ethyl 4-(hydroxymethyl)thiazole-2-carboxylate → HCID 117762896, compound

HRID 2203108Notes

Reaction equation

HRID 2203108 reaction equation
[OH:1][CH2:2][C:3]1[N:4]=[C:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[S:6][CH:7]=1>[O-2].[O-2].[Mn+4].C1COCC1>[CH:2]([C:3]1[N:4]=[C:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[S:6][CH:7]=1)=[O:1]

Participants

4

Reactant 1

HCID 43558808ethyl 4-(hydroxymethyl)thiazole-2-carboxylate

Product 1

HCID 117762896HCID 117762896, compoundYield 91.2%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of ethyl 4-(hydroxymethyl)-1,3-thiazole-2-carboxylate (1.23 g), manganese dioxide (5.71 g) and THF (25 ml) was heated at 50° C. overnight. The inorganic material was removed by filtration, and the filtrate was concentrated in vacuo to give the title compound (1.11 g) as a yellow solid.

Workup

  1. customThe inorganic material was removed by filtration
  2. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-13b540fa9a904ad68b560f2fefb8b9a6
Source dataset
uspto-grants-2016_06
Patent number
US09365540B2

Reaction notes

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