反应详情

To a solution of compound 17 (1 g, 4.2 mmol), at room temperature and under nitrogen atmosphere, in dry dichloromethane (10 mL) were added DIPEA (0.8 mL, 4.62 mmol) and methane sulfonic anhydride. (0.8 g, 4.62 mmol) The resulting mixture was stirred for 2 h. Then, the reaction mixture was quenched with water and the mixture was extracted with more dichloromethane. The organic layer was separated, washed with Brine, dried (MgSO4), filtered and the solvent evaporated to give the desired product as yellow oil.

1. customThen, the reaction mixture was quenched with water
2. extractionthe mixture was extracted with more dichloromethane
3. customThe organic layer was separated
4. washwashed with Brine
5. dry with materialdried (MgSO4)
6. filtrationfiltered
7. customthe solvent evaporated