反应详情

温度

100 °C

A mixture of compound 67 (0.045 g, 0.11 mmol), lithium hydroxide (0.02 g, 0.44 mmol) in a mixture of tetrahydrofuran (2 mL), water (1 mL) and methanol (1 mL) was heated at 100° C. under microwave conditions for 10 minutes. Then, the reaction was quenched by adding water and diluted with ethyl acetate. The organic layer was separated, washed with Brine, dried (MgSO4), filtered and the solvent was evaporated.

1. customThen, the reaction was quenched
2. additionby adding water
3. additiondiluted with ethyl acetate
4. customThe organic layer was separated
5. washwashed with Brine
6. dry with materialdried (MgSO4)
7. filtrationfiltered
8. customthe solvent was evaporated