反应详情

A DMA (250 mL) solution containing 4-chloro-2-fluorobenzaldehyde (50 g, 315 mmol) and hydrazine monohydrate (230 mL, 4730 mmol) was stirred for 30 minutes at room temperature. The solution was then stirred at 100° C. for 17 hours. The reaction mixture, which was a thick white slurry, was cooled to room temperature. The solid was collected by filtration, washed with water and dried under vacuum to give the indicated product.

1. stirringThe solution was then stirred at 100° C. for 17 hours
2. temperaturewas cooled to room temperature
3. filtrationThe solid was collected by filtration
4. washwashed with water
5. customdried under vacuum
6. customto give the indicated product