1-(1H-Imidazol-1-yl)ethanone → HCID 86678974, compound

HRID 2203337Notes

Reaction equation

HRID 2203337 reaction equation
[NH2:1][C:2]1[C:3]2[C:29]([CH3:34])([C:30]([NH:32][NH2:33])=[O:31])[C:28](=[O:35])[NH:27][C:4]=2[N:5]=[C:6]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([Cl:17])=[CH:14][CH:15]=3)[C:10]([CH2:18][CH2:19][C:20]([F:26])([F:25])[C:21]([F:24])([F:23])[F:22])=[N:9]2)[N:7]=1.[C:36](N1C=CN=C1)(=[O:38])[CH3:37]>C1COCC1>[C:36]([N:32]([C:30]([C:29]1([CH3:34])[C:3]2[C:2]([NH2:1])=[N:7][C:6]([N:8]3[C:16]4[C:11](=[CH:12][C:13]([Cl:17])=[CH:14][CH:15]=4)[C:10]([CH2:18][CH2:19][C:20]([F:25])([F:26])[C:21]([F:23])([F:24])[F:22])=[N:9]3)=[N:5][C:4]=2[NH:27][C:28]1=[O:35])=[O:31])[NH2:33])(=[O:38])[CH3:37]

Participants

4

Reactant 2

HCID 171741-(1H-Imidazol-1-yl)ethanoneHCID 86678975HCID 86678975, compound

Product 1

HCID 86678974HCID 86678974, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a THF solution (3 mL) of the intermediate from Step A (100 mg, 0.193 mmol) was added 1-acetylimidazole (85 mg, 0.771 mmol). The resultant mixture was stirred at ambient temperature under a nitrogen atmosphere for 3 hours then purified by preparative TLC using 10% MeOH/1% NH4OH I DCM as eluent to give the indicated product. m/z=561.1 (M+H).

Workup

  1. customthen purified by preparative TLC
  2. customto give the indicated product

Sources & evidence

ORD record
ord-a3ac02fc2dc94228967a33db963cedee
Source dataset
uspto-grants-2016_06
Patent number
US09365574B2

Reaction notes

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