反应详情

温度

120 °C

A DMF (180 mL) solution containing the intermediate from Step B above (24.1 g, 98 mmol), zinc cyanide (6.93 g, 59.0 mmol), 1,1′-bis(diphenylphosphino)ferrocene (4.36 g, 7.87 mmol) and tris(dibenzylideneacetone)dipalladium (3.60 g, 3.93 mmol) was heated at 120° C. for 1.5 hours. The solution was cooled to room temperature and diluted with water. The precipitated product was collected and dried under vacuum with a nitrogen sweep to give the title compound. 1H NMR (400 MHz, CH3CN-d3): δ 12.42 (s, 1H); 8.67 (dd, J=4.48, 1.53 Hz, 1H); 8.29 (dd, J=8.22, 1.53 Hz, 1H); 7.40 (dd, J=8.23, 4.48 Hz, 1H).

1. temperatureThe solution was cooled to room temperature
2. customThe precipitated product was collected
3. customdried under vacuum with a nitrogen sweep