Dimethylformamide → HCID 86679006, compound

HRID 2203369Notes

Reaction equation

HRID 2203369 reaction equation
[NH2:1][C:2]1[C:3]2[C:29]([CH3:36])([C:30]([NH:32][CH:33]3[CH2:35][CH2:34]3)=[O:31])[C:28](=[O:37])[NH:27][C:4]=2[N:5]=[C:6]([C:8]2[C:16]3[C:11](=[N:12][C:13](Cl)=[CH:14][CH:15]=3)[N:10]([CH2:18][CH2:19][C:20]([F:26])([F:25])[C:21]([F:24])([F:23])[F:22])[N:9]=2)[N:7]=1.[CH3:38][N:39](C=O)C>[C-]#N.[Zn+2].[C-]#N.C1(P(C2C=CC=CC=2)[C-]2C=CC=C2)C=CC=CC=1.[C-]1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=C1.[Fe+2].C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[NH2:1][C:2]1[C:3]2[C:29]([CH3:36])([C:30]([NH:32][CH:33]3[CH2:35][CH2:34]3)=[O:31])[C:28](=[O:37])[NH:27][C:4]=2[N:5]=[C:6]([C:8]2[C:16]3[C:11](=[N:12][C:13]([C:38]#[N:39])=[CH:14][CH:15]=3)[N:10]([CH2:18][CH2:19][C:20]([F:26])([F:25])[C:21]([F:24])([F:23])[F:22])[N:9]=2)[N:7]=1

Participants

6

Reactant 2

HCID 6228DimethylformamideHCID 86679007HCID 86679007, compound

Product 1

HCID 86679006HCID 86679006, compound

Reagents, catalysts & solvents 3

HCID 11186Zinc cyanide (Zn(CN)2)CatalystHCID 635956Ferrocene-1,1'-bis-(diphenylphosphine)CatalystHCID 9811564Bis(dibenzylideneacetone)palladiumCatalyst

Conditions

Temperature
130 °C

Procedure

A DMF (4 mL) solution containing 4-amino-2-(6-chloro-1-(3,3,4,4,4-pentafluorobutyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-N-cyclopropyl-5-methyl-6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-5-carboxamide, as described in Example 176, (149 mg, 0.273 mmol), zinc cyanide (19.3 mg, 0.164 mmol), 1,1′-bis(diphenylphosphino)ferrocene (15.16 mg, 0.027 mmol), and tris(dibenzylideneacetone)dipalladium (0) (12.52 mg, 0.014 mmol) was degassed for 1 hour at rt. The reaction mixture was then stirred for 15 hours at 130° C. The reaction mixture was then cooled and ethyl acetate (30 mL) and water (10 mL) were added. The water layer was extracted with ethyl acetate (3×20 mL). The combined organic layer was dried over Na2SO4 and evaporated under reduced pressure. The residue was purified by reverse phase HPLC to afford the indicated product. Chiral separation using SFC on a Chiralcel OD column provided both enantiomers of the title compound. 1NMR (500 MHz, CD3COCD3): δ 0.56 (m, 2H); 0.71 (M, 2H); 1.73 (s, 3H); 2.77 (m, 1H); 3.06 (m, 2H); 5.02 (t, J=7.0 Hz, 2H); 7.00 (br, 2H); 7.52 (br, 1H); 7.84 (d, J=8.2 Hz, 1H); 9.28 (d, J=8.2 Hz, 1H). m/z=536.1 (M+H).

Workup

  1. customwas degassed for 1 hour at rt
  2. temperatureThe reaction mixture was then cooled
  3. additionethyl acetate (30 mL) and water (10 mL) were added
  4. extractionThe water layer was extracted with ethyl acetate (3×20 mL)
  5. dry with materialThe combined organic layer was dried over Na2SO4
  6. customevaporated under reduced pressure
  7. customThe residue was purified by reverse phase HPLC
  8. customto afford the indicated product
  9. customChiral separation

Sources & evidence

ORD record
ord-ac80c598bc8d485b8c419bc0fa93852e
Source dataset
uspto-grants-2016_06
Patent number
US09365574B2

Reaction notes

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