反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 85 °C
PROCEDURE
实验过程
To a mixture of 4-amino-N,N-dicyclopropyl-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide (example 1J, 30 mg, 0.089 mmol), 2-bromothiazole (11.98 μL, 0.133 mmol), Pd2(dba)3 (12.18 mg, 0.013 mmol), BINAP (24.84 mg, 0.040 mmol) and sodium tert-butoxide (13.63 mg, 0.142 mmol) was added PhMe (887 μL). The mixture was sparged with argon gas for 5 min and heated to 85° C. for 5.5 h. The reaction mixture was filtered through a plug of Celite and concentrated. The crude residue was purified by preparative HPLC to provide N,N-dicyclopropyl-6-ethyl-1-methyl-4-(thiazol-2-ylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide (4 mg, 10.49% yield) along with some recovered starting material.
WORKUP
后处理
- customThe mixture was sparged with argon gas for 5 min
- filtrationThe reaction mixture was filtered through a plug of Celite
- concentrationconcentrated
- customThe crude residue was purified by preparative HPLC