反应详情

温度

80 °C

NaH (80 mg, 2.0 mmol) was added to a mixture of oxetan-3-ol (150 mg, 2.0 mmol) and DMF (2 mL) at 0° C. The reaction was allowed to stir for 10 minutes before methyl 3,4-difluorobenzoate (170 mg, 1.0 mmol) was added. The reaction was then heated at 80° C. overnight. The reaction was quenched with brine and was extracted with EtOAc (3×). The combined organic layers were dried over sodium sulfate and the solvent was removed to give methyl 3-fluoro-4-(oxetan-3-yloxy)benzoate. ESI-MS m/z calc. 226.1, found 227.2 (M); Retention time: 2.36 minutes (4 min run).

1. additionwas added
2. customThe reaction was quenched with brine
3. extractionwas extracted with EtOAc (3×)
4. dry with materialThe combined organic layers were dried over sodium sulfate
5. customthe solvent was removed