反应详情

Couple 2,3-dichloropyrazine (0.302 g, 2.03 mmol) and 4-chlorophenylboronic acid (0.320 g, 2.05 mmol), using tetrakis(triphenylphosphine)palladium(0) (0.124 g, 0.107 mmol), and potassium fluoride (0.355 g, 6.11 mmol) in toluene (19 mL) and water (5 mL), at 100° C. for 17.5 hr. Cool the reaction, partition the layers and extract the aqueous layer with ethyl acetate. Wash the combined organic layers with saturated aqueous sodium chloride, dry (magnesium sulfate), concentrate and purify (silica gel chromatography, eluting with 0:100 to 35:65 ethyl acetate:hexanes), to give 2-chloro-3-(4-chlorophenyl)-pyrazine (0.199 g, 44%).

1. temperatureCool
2. customthe reaction
3. custompartition the layers
4. extractionextract the aqueous layer with ethyl acetate
5. washWash the combined organic layers with saturated aqueous sodium chloride
6. dry with materialdry (magnesium sulfate)
7. concentrationconcentrate
8. custompurify
9. wash(silica gel chromatography, eluting with 0:100 to 35:65 ethyl acetate:hexanes)