(4-Methoxyphenyl)boronic acid → 2-Chloro-3-(4-methoxyphenyl)pyrazine

HRID 220430Notes

Reaction equation

HRID 220430 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11](Cl)=[CH:10][CH:9]=2)=[N:6][CH:5]=[CH:4][N:3]=1.[CH3:15][O:16]C1C=CC(B(O)O)=CC=1>>[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([O:16][CH3:15])=[CH:10][CH:9]=2)=[N:6][CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 201262(4-Methoxyphenyl)boronic acidHCID 131998892-Chloro-3-(4-chlorophenyl)pyrazine

Product 1

HCID 131998882-Chloro-3-(4-methoxyphenyl)pyrazineYield 54%

Procedure

Use the method used to make 2-chloro-3-(4-chlorophenyl)-pyrazine, using 4-methoxyphenylboronic acid to obtain 2-chloro-3-(4-methoxyphenyl)-pyrazine (54% yield).

Sources & evidence

ORD record
ord-0d5c38724c0c4658b6308547876c67c1
Source dataset
uspto-grants-2012_06
Patent number
US08202873B2

Reaction notes

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