HCID 86703200, compound → HCID 86703199, compound

HRID 2204392Notes

Reaction equation

HRID 2204392 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([C:10]2[N:14]([CH:15]([CH3:17])[CH3:16])[C:13]3[CH:18]([C:39]4[CH:46]=[CH:45][C:42]([C:43]#[N:44])=[CH:41][CH:40]=4)[N:19]([C:22]4[C:23](=[O:38])[N:24](CC5C=CC(OC)=CC=5)[CH:25]=[C:26]([Cl:28])[CH:27]=4)[C:20](=[O:21])[C:12]=3[CH:11]=2)=[CH:4][N:3]=1>C(O)(C(F)(F)F)=O>[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([C:10]2[N:14]([CH:15]([CH3:17])[CH3:16])[C:13]3[CH:18]([C:39]4[CH:40]=[CH:41][C:42]([C:43]#[N:44])=[CH:45][CH:46]=4)[N:19]([C:22]4[C:23](=[O:38])[NH:24][CH:25]=[C:26]([Cl:28])[CH:27]=4)[C:20](=[O:21])[C:12]=3[CH:11]=2)=[CH:4][N:3]=1

Participants

3

Reactant 1

HCID 86703200HCID 86703200, compound

Product 1

HCID 86703199HCID 86703199, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 4-{2-(2-amino-4-methoxy-pyrimidin-5-yl)-5-[5-chloro-1-(4-methoxy-benzyl)-2-oxo-1,2-dihydro-pyridin-3-yl]-1-isopropyl-4-oxo-1,4,5,6-tetrahydro-pyrrolo[3,4-b]pyrrol-6-yl}-benzonitrile (Step 125.1) (0.137 mmol) in TFA (1 mL) was stirred at 100° C. for 30 min and then the reaction mixture was concentrated. The residue was purified by flash chromatography to afford the title compound as a white solid. ESI-MS: tR=0.75 min, [M+]+516/518 (LC-MS 1).

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was purified by flash chromatography

Sources & evidence

ORD record
ord-b06f2024908c49da86fdb3070833263b
Source dataset
uspto-grants-2016_06
Patent number
US09365576B2

Reaction notes

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