Trifluoroacetic acid → HCID 68594817, compound

HRID 220443Notes

Reaction equation

HRID 220443 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:15]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)=[N:16][CH:17]=[CH:18][CH:19]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[F:26][C:23]1[CH:24]=[CH:25][C:20]([C:15]2[C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[CH:19][CH:18]=[CH:17][N:16]=2)=[CH:21][CH:22]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 687228274-[2-(4-Fluorophenyl)-pyridin-3-yl]-piperazine-1-carboxylic acid t-butyl ester

Product 1

HCID 68594817HCID 68594817, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Dissolve 4-[2-(4-fluorophenyl)-pyridin-3-yl]-piperazine-1-carboxylic acid t-butyl ester (0.9 g, 2.52 mmol) in DCM (25 mL). Add trifluoroacetic acid (8.6 g, 5.8 mL, 75.6 mmol). Stir the mixture at room temperature for 2 hr. Purify by a SCX ion-exchange column to give the title preparation. MS (ES): m/z=258 [M+H].

Workup

  1. customPurify by a SCX ion-exchange column
  2. customto give the title
  3. custompreparation

Sources & evidence

ORD record
ord-c48641fd662344d69e2693afb2606ef8
Source dataset
uspto-grants-2012_06
Patent number
US08202873B2

Reaction notes

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