反应详情

温度

50 °C

Methyl 4-bromo-2-hydroxy-5-(4-morpholinylmethyl)benzoate (may be prepared as described in Description 17; 350 mg, 0.96 mmol) was redissolved in tetrahydrofuran (4 ml) and lithium hydroxide (69 mg, 2.87 mmol) was added followed by water (1 ml). The mixture was heated at 50° C. for 1 hour. The mixture was cooled and the solvent removed in vacuo to yield the title compound as a brown oil. 302 mg.

1. temperatureThe mixture was cooled
2. customthe solvent removed in vacuo