Morpholine → HCID 66611934, compound

HRID 2204704Notes

Reaction equation

HRID 2204704 reaction equation
C([O:4][C:5]1[CH:14]=[C:13]([CH2:15]Br)[C:12]([C:17]([F:20])([F:19])[F:18])=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8])(=O)C.C(N(CC)CC)C.[NH:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>CC(C)=O>[OH:4][C:5]1[CH:14]=[C:13]([CH2:15][N:28]2[CH2:33][CH2:32][O:31][CH2:30][CH2:29]2)[C:12]([C:17]([F:18])([F:19])[F:20])=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8]

Participants

5

Reactant 3

HCID 8083MorpholineHCID 8471TriethylamineHCID 66611624HCID 66611624, compound

Product 1

HCID 66611934HCID 66611934, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of methyl 2-(acetyloxy)-4-(bromomethyl)-5-(trifluoromethyl)benzoate (may be prepared as described in Description 47; 309 mg, 0.87 mmol) in acetone (5 ml) was added triethylamine (0.24 ml, 1.74 mmol) and morpholine (0.10 ml, 1.13 mmol) the solution was stirred for 2 hours. The solvent was removed in vacuo and the residue was dissolved in ethyl acetate (10 ml), washed with water (10 ml), dried (MgSO4) and the solvent removed in vacuo to give the title compound. 300 mg.

Workup

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue was dissolved in ethyl acetate (10 ml)
  3. washwashed with water (10 ml)
  4. dry with materialdried (MgSO4)
  5. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-5ced269eef7844a6a8bc586acf756d49
Source dataset
uspto-grants-2016_06
Patent number
US09365551B2

Reaction notes

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