反应详情

温度

150 °C

Combine 1H-pyrazole-4-carbaldehyde (0.150 g, 1.56 mmol), racemic 1-bromo-2-propanol (0.260 g, 1.87 mmol), and potassium carbonate (0.323 g, 2.34 mmol) in acetonitrile (2 mL). Heat in microwave at 150° C. for 20 min. Filter, wash with acetonitrile and concentrate filtrate. Purify via silica gel chromatography, eluting with 0:100 to 100:0 ethyl acetate:hexanes) to give the title preparation (177 mg, 73%). GC-MS: m/z=154 [M+].

1. filtrationFilter
2. washwash with acetonitrile
3. concentrationconcentrate filtrate
4. customPurify via silica gel chromatography
5. washeluting with 0:100 to 100:0 ethyl acetate
6. customhexanes) to give the title
7. custompreparation (177 mg, 73%)