3,4-(Methylenedioxy)phenylacetonitrile → HCID 71272006, compound

HRID 2204916Notes

Reaction equation

HRID 2204916 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:18]=[CH:17][C:14]([CH:15]=O)=[CH:13][C:12]=1[O:19][CH3:20].[O:21]1[C:25]2[CH:26]=[CH:27][C:28]([CH2:30][C:31]#[N:32])=[CH:29][C:24]=2[O:23][CH2:22]1>>[O:21]1[C:25]2[CH:26]=[CH:27][C:28](/[C:30](=[CH:15]/[C:14]3[CH:17]=[CH:18][C:11]([O:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][OH:1])=[C:12]([O:19][CH3:20])[CH:13]=3)/[C:31]#[N:32])=[CH:29][C:24]=2[O:23][CH2:22]1

Participants

3

Reactant 2

HCID 781783,4-(Methylenedioxy)phenylacetonitrileHCID 59839085HCID 59839085, compound

Product 1

HCID 71272006HCID 71272006, compoundYield 99%

Procedure

(2Z)-2-(1,3-benzodioxol-5-yl)-3-{4-[(8-hydroxyoctyl)oxy]-3-methoxyphenyl}prop-2-enenitrile is prepared starting from 4-[(8-hydroxyoctyl)oxy]-3-methoxybenzaldehyde and 1,3-benzodioxol-5-ylacetonitrile according the same procedure following for example 10 in 99% yield. This material proves chromatographically homogenous and displays spectral characteristics consistent with its assigned structure.

Sources & evidence

ORD record
ord-3a0378c08eb54465aa8fd2031525f303
Source dataset
uspto-grants-2016_06
Patent number
US09366906B2

Reaction notes

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