Hydrochloric Acid → HCID 86678297, compound

HRID 2205013Notes

Reaction equation

HRID 2205013 reaction equation
[N:1]([CH2:4][CH2:5][CH2:6][C:7]([P:10](=[O:17])([O:14][CH2:15][CH3:16])[O:11][CH2:12][CH3:13])([F:9])[F:8])=[N+]=[N-].[ClH:18].CCOCC>CCO.[OH-].[Pd+2].[OH-]>[ClH:18].[NH2:1][CH2:4][CH2:5][CH2:6][C:7]([P:10](=[O:17])([O:14][CH2:15][CH3:16])[O:11][CH2:12][CH3:13])([F:8])[F:9]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 86678296HCID 86678296, compound

Product 1

HCID 86678297HCID 86678297, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

To a solution of diethyl 4-azido-1,1-difluorobutylphosphonate (1 eq) in EtOH (2 M) was added palladium hydroxide (0.05 eq) and 2 M HCl in ether (1.1 eq). The reaction mixture was stirred under hydrogen (1 atm) overnight. The palladium was filtered off and the filtrate was concentrated en vaccuo. The crude mixture was used for the next reaction without further purification.

Workup

  1. filtrationThe palladium was filtered off
  2. concentrationthe filtrate was concentrated en vaccuo
  3. customThe crude mixture was used for the next reaction without further purification

Sources & evidence

ORD record
ord-82a7aede0b5e4728b18c0c4e6b40ec49
Source dataset
uspto-grants-2016_06
Patent number
US09365506B2

Reaction notes

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