反应详情

A solution of (5R,9R)-tert-butyl 9-(dodecyloxy)-1-(9H-fluoren-9-yl)-3-oxo-2,11-dioxa-7-thia-4-azatricosane-5-carboxylate in 50% TFA in DCM (0.3 M) was stirred at room temperature until complete deprotection of tert-butyl group (30 minutes). The reaction mixture was diluted in MTBE, washed three times with 1M citric acid (adjusted to pH3), and once with 1:2 1N HCl/brine. The organic layer was dried over anhydrous Na2SO4 and concentrated en vaccuo. The resulting waxy solid was used for the next step without further purification.

1. washwashed three times with 1M citric acid (adjusted to pH3)
2. dry with materialThe organic layer was dried over anhydrous Na2SO4
3. concentrationconcentrated en vaccuo
4. customThe resulting waxy solid was used for the next step without further purification