Trifluoroacetic acid → HCID 178440669, compound

HRID 22053Notes

Reaction equation

HRID 22053 reaction equation
[CH2:1]([C:5]1[N:13]2[C:8]([C:9]([CH2:31][C:32]([O:34]C(C)(C)C)=[O:33])=[CH:10][CH2:11][CH:12]2[C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].C(O)(C(F)(F)F)=O>C(Cl)(Cl)Cl>[CH2:1]([C:5]1[N:13]2[C:8]([C:9]([CH2:31][C:32]([OH:34])=[O:33])=[CH:10][CH2:11][CH:12]2[C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:27][N:28]=[N:29][N:30]=3)=[CH:16][CH:15]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178440671HCID 178440671, compound

Product 1

HCID 178440669HCID 178440669, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of biphenyl indolizinyl tert-butyl ester (0.039 mmol, the title compound of Example 1926) in 0.5 mL of chloroform is added 0.25 mL of TFA, and the progress of the reaction is monitored by 1H NMR. The resulting solution is stirred at room temperature until the reaction is complete. The mixture is quenched with methanol and concentrated in vacuo. The residue is purified to give the title compound of Example 1927.

Workup

  1. customThe mixture is quenched with methanol
  2. concentrationconcentrated in vacuo
  3. customThe residue is purified

Sources & evidence

ORD record
ord-7a69ec3f750544abae4ab67643caedf2
Source dataset
uspto-grants-1995_06
Patent number
US05426105

Reaction notes

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