Potassium Carbonate → HCID 89544837, compound

HRID 2205590Notes

Reaction equation

HRID 2205590 reaction equation
[N:1]1(C(OC(C)(C)C)=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[C:7]([O:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=1)=[O:8].BrCCOC1C=CC(OC)=C(OC)C=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O.C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[C:7]([O:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=1)=[O:8]

Participants

7

Reactant 3

HCID 11430Potassium CarbonateHCID 22324249HCID 22324249, compoundHCID 89939884HCID 89939884, compound

Product 1

HCID 89544837HCID 89544837, compound

Reagents, catalysts & solvents 3

HCID 180AcetoneSolventHCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

1-tert-Butyl 2-(2-(3,4-dimethoxyphenoxy)ethyl) piperidine-1,2-dicarboxylate (456 mg, 1.1 mmol), prepared by reacting 1-tert-butyl-piperidine-1,2-dicarboxylate and 4-(2-bromoethoxy)-1,2-dimethoxybenzene in acetone in the presence of potassium carbonate, was dissolved in 10 ml 20% TFA in DCM and was stirred at room temperature for 2 h. The reaction mixture was concentrated in vacuo and used for next step without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customused for next step without further purification

Sources & evidence

ORD record
ord-7ac6b6e4b7b646d6ad14edee311f7a89
Source dataset
uspto-grants-2016_06
Patent number
US09371322B2

Reaction notes

Loading…