反应详情

Crude 5-chloro-1-isobutyl-6-(4-methoxybenzyl)-3-methyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (2.5 g) is dissolved in 5 mL of methylene chloride containing TFA (2 mL) and TFMSA (1.6 mL). The reaction mixture is stirred at room temperature overnight. After routine workup, the obtained crude product is purified by column chromatography to give 730 mg of product as gray solids. MS (ESI) m/z 256.1 [M+H]+.

1. customAfter routine workup, the obtained crude product
2. customis purified by column chromatography