Chlorosuccinimide → HCID 64318084, compound

HRID 2205902Notes

Reaction equation

C1C(=O)N([Cl:8])C(=O)C1.[CH3:9][N:10]1[CH:14]=[N:13][N:12]=[C:11]1[C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=1>CN(C=O)C>[Cl:8][C:20]1[CH:21]=[C:15]([C:11]2[N:10]([CH3:9])[CH:14]=[N:13][N:12]=2)[CH:16]=[CH:17][C:18]=1[NH2:19]

Participants

Conditions

Temperature: 90 °C

Procedure

NCS (0.077 g, 0.574 mmol) was added to a solution of 4-(4-methyl-4H-1,2,4-triazol-3-yl)aniline (0.1 g, 0.574 mmol) in DMF (1.1 mL). The reaction mixture was heated at 90° C. for 1 hour and was then concentrated under vacuum. The residue was purified via Biotage silica gel column chromatography elutin with (DCM/EtOH 99/1 to 90/10) to afford the title product as a white solid (97 mg, 81%). 1H NMR (500 MHz, CD3OD) δ 3.78 (s, 3H), 6.95 (d, J=8.4 Hz, 1H), 7.38 (dd, J=8.4, 2.0 Hz, 1H), 7.58 (d, J=2.0 Hz, 1H), 8.48 (s, 1H). LC (Method B)-MS (ESI, m/z) tR 1.25 min, 209 [(M+H+), 100%].

Workup

concentrationwas then concentrated under vacuum
customThe residue was purified via Biotage silica gel column chromatography elutin with (DCM/EtOH 99/1 to 90/10)

Sources & evidence

ORD record: ord-bc4114a2f04f442a947bad60adad3c9e
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09371319B2

Reaction notes

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