Hydrochloric Acid → HCID 137010740, compound

HRID 2206205Notes

Reaction equation

HRID 2206205 reaction equation
[Cl:1][C:2]1[C:3]2[N:11]([C:12]3[C:17]([F:18])=[CH:16][CH:15]=[CH:14][C:13]=3[F:19])[N:10]=[C:9]([C:20]3[CH:25]=[CH:24][C:23]([N:26]4[CH2:31][CH2:30][O:29][CH2:28][CH2:27]4)=[CH:22][CH:21]=3)[C:4]=2[C:5](=[O:8])[NH:6][CH:7]=1.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[C:3]2[N:11]([C:12]3[C:17]([F:18])=[CH:16][CH:15]=[CH:14][C:13]=3[F:19])[N:10]=[C:9]([C:20]3[CH:21]=[CH:22][C:23]([N:26]4[CH2:27][CH2:28][O:29][CH2:30][CH2:31]4)=[CH:24][CH:25]=3)[C:4]=2[C:5](=[O:8])[NH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 137010681HCID 137010681, compound

Product 1

HCID 137010740HCID 137010740, compoundYield 151.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 7-chloro-1-(2,6-difluorophenyl)-3-(4-(morpholin-4-yl)phenyl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one (100 mg) obtained in Example 161 in ethanol (10 mL) was added 6M hydrochloric acid (0.102 mL) at room temperature, and the reaction mixture was concentrated. The residue was crystallized from ethanol to give the title compound (82 mg).

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was crystallized from ethanol

Sources & evidence

ORD record
ord-4b1710df7f114295be044f79896f09da
Source dataset
uspto-grants-2016_06
Patent number
US09371320B2

Reaction notes

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