Methylamine → HCID 69093508, compound

HRID 2206310Notes

Reaction equation

HRID 2206310 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:12]2[C:21]3[C:16](=[C:17]4[CH:25]=[CH:24][CH:23]=[CH:22][C:18]4=[CH:19][CH:20]=3)[O:15][C:14]([NH2:26])=[C:13]2[C:27]2[N:31]=[C:30]([CH2:32]Cl)[O:29][N:28]=2)[CH:5]=[C:6]([O:10][CH3:11])[C:7]=1[O:8][CH3:9].[CH2:34]([N:36](CC)CC)C.CN>C(#N)C.O>[Br:1][C:2]1[CH:3]=[C:4]([CH:12]2[C:21]3[C:16](=[C:17]4[CH:25]=[CH:24][CH:23]=[CH:22][C:18]4=[CH:19][CH:20]=3)[O:15][C:14]([NH2:26])=[C:13]2[C:27]2[N:31]=[C:30]([CH2:32][NH:36][CH3:34])[O:29][N:28]=2)[CH:5]=[C:6]([O:10][CH3:11])[C:7]=1[O:8][CH3:9]

Participants

6

Reactant 3

HCID 6329MethylamineHCID 8471TriethylamineHCID 69085097HCID 69085097, compound

Product 1

HCID 69093508HCID 69093508, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Procedure

4-(3-Bromo-4,5-dimethoxy-phenyl)-3-(5-chloromethyl-[1,2,4]oxadiazol-3-yl)-4H-benzo[h]chromen-2-ylamine (24) (528 mg, 1 mmol) and triethylamine (140 μl, 1 mmol) and 2M methanolic solution of methylamine (600 μl, 1.2 mmol) is taken in acetonitril (10 ml) and stirred at room temperature under LC-MS control till the reaction is complete. The reaction mixture is diluted with water to about 50 ml and stirred for 2 h at room temperature. Thus resulting precipitates are separated by filtration, washed well with water and is dried under high vacuum to get solids of the title compound.

Workup

  1. stirringstirred for 2 h at room temperature
  2. customThus resulting
  3. customprecipitates
  4. customare separated by filtration
  5. washwashed well with water
  6. customis dried under high vacuum

Sources & evidence

ORD record
ord-5e18f1448f734fbe9298d48b2d2b8b0d
Source dataset
uspto-grants-2016_06
Patent number
US09371333B2

Reaction notes

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