Hydrochloric Acid → HCID 66678332, compound

HRID 220643Notes

Reaction equation

HRID 220643 reaction equation
[OH:1][CH2:2][CH2:3][C@H:4]([NH:15]C(=O)OC(C)(C)C)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]([F:14])([F:13])[F:12].[ClH:23]>O1CCOCC1>[ClH:23].[NH2:15][C@H:4]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]([F:12])([F:13])[F:14])[CH2:3][CH2:2][OH:1]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59536826HCID 59536826, compound

Product 1

HCID 66678332HCID 66678332, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Of the compound from Example 79A, 150 mg (0.47 mmol) were stirred for 20 min in 3 ml of a 4N solution of hydrogen chloride in dioxane. The volatile components were removed on a rotary evaporator and the residue was dried in an HV. This gave 140 mg (87% purity) of the title compound.

Workup

  1. customThe volatile components were removed on a rotary evaporator
  2. customthe residue was dried in an HV

Sources & evidence

ORD record
ord-95051fc9e06e4a8b997d6aaf8448f5a1
Source dataset
uspto-grants-2012_06
Patent number
US08202895B2

Reaction notes

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